Development of a device for controlled drug release by acoustic wave

הרקע לפרויקט:

Today, many drugs have unacceptable side effects due to the drug’s interaction with healthy tissues that are not the target site. Drug delivery systems are engineered technologies for targeted delivery and/or controlled release of therapeutic agents. Drug delivery systems that respond to external stimuli are of great research interest as they enable the controlled release of drugs according to external alterations. Many physical and chemical stimuli can be triggered, such as temperature, pH, light, electric fields, magnetic fields, osmotic pressure, and ultrasound (US). The US attracts great attention due to its many advantages: absence of ionizing radiations, low cost, ease of operation, and the ability to transmit energy to precise locations. Our goal is to develop an implantable device loaded with drugs for remote and controlled release of the drug.

מטרת הפרויקט:

The students will design and fabricate a polymeric-based device for controlled drug delivery by acoustic waves. They will experimentally examine the effect of acoustic waves on the device and cells in the culture.

תכולת הפרויקט:

• Review the field of drug release by external stimulation by acoustic waves.
• Fabricating polymer-drug device, and releasing drugs from it by acoustic waves.
• Examination of the effect of a few parameters on the drug release, including device and acoustic parameters.
• Biological interface - examination of the influence of the polymer-drug device and the acoustic system on cells.

קורסי קדם:

• פזיולוגיה כמותית
• דימות רפואי

מקורות:

• Kim, H. J.; Matsuda, H.; Zhou, H.; Honma, I. Ultrasound-Triggered Smart Drug Release from a Poly(Dimethylsiloxane)- Mesoporous Silica Composite. Advanced Materials 2006, 18 (23), 3083–3088.
• Cohen, S.; Sazan, H.; Kenigsberg, A.; Schori, H.; Piperno, S.; Shpaisman, H.; Shefi, O. Large-scale acoustic-driven neuronal patterning and directed outgrowth. Scientific Report 2020, 10.
• A. Stewart, S.; Domínguez-Robles, J.; F. Donnelly R.; Larrañeta, E. Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications. Polymers 2018, 10, 1379.