Biomedical Systems Advancement via CMOS Micro-Nano Technology
Abstract: CMOS technology has been the drive for digital circuits in the past decades. CMOS image sensors "piggy-backed" on the technology roadmap and enabled the 2nd solid state image sensor generation, CMOS Active Pixel Sensor, featuring low power, low mass and low cost sensing. The main advantage this technology offered was the possibility of integration of additional functionality within the sensor, which enabled, for instance, wide dynamic range. This is important in different applications where both dim light and very strong light levels can be present in an input scene, as commonly viewed in Bio-medical imaging. A specific image sensor with dual extension of the dynamic range is described, incorporating it as the heart of a contact imager set to monitor neuron activity via florescence. The imager is coated with a special optical filter, enabling a truly compact optical capture device.