Image-Guided Cancer Nano Theranostics
The development of biocompatible nanoparticles for molecular imaging and targeted cancer therapy is an area of considerable current interest across a number of disciplines. The premise is that nanoparticles possess unique structural and functional properties that are not available from either small-molecular-weight molecules or bulk materials. However, successful delivery of nanomaterials to the tumor sites requires overcoming many biological barriers, including extravazation from tumor vasculature and dispersion of nanoparticles from perivascular area. In my presentation, I will share our experiences towards enhanced delivery of nanoparticles to solid tumors, the development of multi-functional nanoplatforms for image-guided multimodal therapy, and the use of radiation and near-infrared laser as external energy source to facilitate tumor delivery of anticancer drugs mediated by nanoparticles. My discussion will be exemplified by three classes of nanomaterials: water-soluble polymer-drug conjugates, hollow gold nanospheres, and semiconductor nanoparticles.